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(A) Ribbon diagram of TNF-α dimer interaction with SPD304 (green) (PDB ID: 2AZ5). (B) Ribbon diagram of the TNF-α trimer (PDB ID: 3ALQ) showing the interface contacts for each monomer. Side chains of Tyr59, Tyr119, and Tyr151 (shown in stick form) of each monomer are located at the center of the interface. Removing one of the monomers would significantly affect the environment of the Tyr residues in the remaining monomers.
