Table 1. Solubility of SPD304 in 10 mM Citrate-Phosphate Buffer (pH 6.5) Containing Various Concentrations of Different Organic Solventsa.
solubility of SPD304 (μM) | |||
---|---|---|---|
solvent/concn | 2.5% (v/v) | 5% (v/v) | 10% (v/v) |
DMSO | 33 | 52 | 79 |
DMF | 35 | 58 | 82 |
glycerol | 15 | 19 | 28 |
MeOH | 37 | 58 | 83 |
PEG3350 | 71 | 84 | 96 |
PEG5000 | 90 | 97 | >100 |
The solubility of SPD 304 in 0% solvent is 10 μM. The mean values of four independent measurements are presented.