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AM-5262 improves glucose metabolism in high-fat fed/STZ treated mice. (A) Glucose and (B) insulin levels during an OGTT in response to treatments indicated in the figure legends. Compounds were dosed orally at −60 min, and oral glucose was administered at 0 min. (C) Total (bound + free) drug levels in the plasma 1 h post-drug dose during the OGTT.
