Table 1. Fold change in EC50 compared to TGR5WT.
name | WT | N93A | N93D | E169A | N76A | Y89A | Y89F | S270A |
---|---|---|---|---|---|---|---|---|
LCA (1) | 0.73 μM | >1000 | 39.1 | 0.6 | 13.9 | 1.10 | >1000 | |
CA (2) | 19.83 μM | >1000 | 29.1 | 0.8 | 81.9 | 0.22 | >1000 | |
CDCA (3) | 10.29 μM | >1000 | 69.5 | 1.0 | 88.4 | 0.18 | >1000 | |
S-EMCA (4) | 0.18 μM | >1000 | 52.4 | 3.9 | >100 | 1.45 | >1000 | |
ECDCA (5) | 0.10 μM | >1000 | 9.4 | 25.5 | 1.4 | >100 | 0.82 | >1000 |
6 | 1.32 μM | >1000 | >1000 | 1.70 | >1000 |