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. 2013 Oct 15;4(12):1158–1162. doi: 10.1021/ml400247k

Table 1. Fold change in EC50 compared to TGR5WT.

graphic file with name ml-2013-00247k_0006.jpg

name WT N93A N93D E169A N76A Y89A Y89F S270A
LCA (1) 0.73 μM >1000   39.1 0.6 13.9 1.10 >1000
CA (2) 19.83 μM >1000   29.1 0.8 81.9 0.22 >1000
CDCA (3) 10.29 μM >1000   69.5 1.0 88.4 0.18 >1000
S-EMCA (4) 0.18 μM >1000   52.4 3.9 >100 1.45 >1000
ECDCA (5) 0.10 μM >1000 9.4 25.5 1.4 >100 0.82 >1000
6 1.32 μM   >1000     >1000 1.70 >1000