Table 1. Structure, in Vitro Data, and Pharmacokinetic Data for Compound 1 in Rat, Dog, and Monkey.

B-RafV600E IC50 (nM)	pERK IC50 (nM)	SKMEL28 proliferation IC50 (nM)	species	intrinsic Clia	Clb	po DNAUCc	% F
3.8	23	48	rat	9	9d	1748d	85
			dog	53	38e	42e	10
			monkey	8	39e	23e	5

^aIntrinsic clearance data from liver microsomes, reported in units of milliliters per minute per gram of liver.

^bIntravenous blood clearance reported in units of milliliters per minute per kilogram.

^cOral dose-normalized AUC (DNAUC) reported as nanograms hour per milliliter per milligram per kilogram (n = 3).

^dDosing vehicle: 1% DMSO, 10% solutol in saline or water, at pH 5.0.

^eDosing vehicle: 1% DMSO, 30% PEG400 in saline or water, at pH 3.5–4.5.