. 2013 Oct 15;4(12):1173–1177. doi: 10.1021/ml400260b

Table 1. IC₅₀ Values for Inhibition of Enzyme Activity by Test 2-Arylquinazolin-4-ones.

compd	TNKS-1 IC₅₀ (nM)	TNKS-2 IC₅₀ (nM)	PARP-1 IC₅₀ (nM)	IMPDH2 IC₅₀ (μM)
1	17	9.6	1200	>10
7a	42	41	795	>10
7b	35	6.7	685	>10
7c	48	10	>5000^a	>10
7d	32	30	104	>10
7e	37	12	891	>10
7f	36	33	>5000^a	>10
7g	32	5.5	>5000^a	>10
7h	44	40	>5000^a	>10
7j	35	3.3	504	>10
7k	52	5.5	1200	>10
10	73	44	>5000^a	>10
11	ND^b	∼100	ND^b	ND^b

Limited by solubility.

Not determined.

Table 1. IC50 Values for Inhibition of Enzyme Activity by Test 2-Arylquinazolin-4-ones.