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IGF-1R reaction progress and reversibility curves in the presence of OSI-906 and compound 1 in a continuous Omnia assay format. (a) IGF-1R activity is linear with time (R2 > 0.9) in the presence of varying concentrations of OSI-906; (b) IGF-1R progress curves measured in the presence of compound 1 are nonlinear and demonstrate time-dependent inhibition; (c) recovery of IGF-1R activity upon dilution into assay mix (RFU, relative fluorescence units).
