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In vivo PD and TGI studies in GEO tumor xenografts. (a) Compound 2: single dose PD study at 2 mg/kg dose, sustained inhibition of pIGF-1R and pIR was observed for 48 h. (b) Compound 2: 66% TGI observed at 2 mg/kg every 7 days (Q7D × 2) dose. (c) Compound 1: 64% TGI observed at 5 mg/kg every day (QD 1–14). Plotted data are mean tumor volumes expressed as a percentage of initial volume ± SE.
