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Compound 6 inhibits NEU4 cleavage of a glycolipid substrate, GM3. An IC50 curve demonstrating the inhibition of glycolipid hydrolysis catalyzed by NEU4 with compound 6.20 The determined IC50 for 6 was 0.74 ± 0.07 μM, and that for DANA was 260 ± 40 μM, demonstrating an approximately 350-fold difference in activity. Assays were performed with four replicates for each point; error bars indicate the standard deviation.
