Table 1. Structures, Molecular Weights, and MDM2 Binding Activity for RG7112 and Its Fragments.

compd	1	2	3	4	5	6	7	8	9	10	11
MW	727.78	70.09	112.56	246.35	305.2	236.31	356.89	478.65	495.48	565.56	554.75
NMR binding?	yes	no	no	no	yes	no	yes	no	yes	yes	yes
SPR binding? (Kd, μM)	0.22	no	no	no	26	no	no	no	20	14	1000
ligand efficiency	0.18				0.31				0.19	0.18	0.10