Table 2. Summary of Rat Pharmacokinetic Parameters for LSP1-2111 Generated Using Noncompartmental Analysis in WinNonlin 5.2^a.

parameter	units	intravenous (IV)b	oral (PO)b
dose	mg/kg	1	10
t1/2	h	0.3
Cmax	ng/mL		92
tmax	h		1.4
Clp	mL/min × kg	6.2
Vss	L/kg	0.1
AUCinf	μg × h/mL	2.8	0.2
F	%		0.8

^aLSP1-2111 (3) was dosed as a solution in saline buffered to pH 7.4, at a dose volume of 5 mL/kg.

^bMean values (N = 2).