Table 3. Potency and Onset Time of β2-Adrenoceptor Agonism in Isolated Tissuea.
compd | guinea pig onset time (min) | human onset time (min) | cLogP | type |
---|---|---|---|---|
AZD3199 | 22 | 11 | 6.0 | dibasic |
1 | 90 | n/d | 4.5 | monobasic |
7 | 6 | n/d | 3.7 | dibasic |
14 | 13 | n/d | 4.9 | dibasic |
16 | 11 | n/d | 5.5 | dibasic |
sibenadet | 58 | n/d | 2.5 | monobasic |
indacaterol | 77 | 49 | 3.0 | monobasic |
formoterol | 23 | 13 | 1.3 | monobasic |
salmeterol | 90 | t/s | 3.1 | monobasic |
salbutamol | 3 | 19 | 0.1 | monobasic |
n/d = not determined; t/s = onset time too slow to measure.