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. 2014 Feb 3;5(4):405–410. doi: 10.1021/ml400531d

Figure 5.

Figure 5

HT2210 and HT2106 inhibit i-20S β5i activity in cell free extracts and intact cells, leading to accumulation of polyubiquitinated proteins. (A) Inhibition of i-20S β5i activity in Karpas 1106p cell lysates; (B) Inhibition of 26S proteasomal activity in Karpas 1106p cells: ●, HT2210; ○, HT2106. (C) Western blot analysis of polyubiquitinated proteins of Karpas 1106p cells treated with HT2210, HT2106, or bortezomib at indicated concentrations for 4 h at 37 °C. Data were the representative of three independent experiments.