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Neuritogenic activity of farinosone C (3) and its simplified analogs (4–24) in the PC12 assay. All values were determined at 50 μM, except the following: a, 20 μM; b, 5 μM; c, 10 μM. Positive control: nerve growth factor (NGF), 20 ng mL–1. Solvent control: DMSO (0.1%). Incubation period: 2 days. Values are reported as mean (unpaired t test; confidence interval 95%; significance: *** = P < 0.0001, n = 3, mean ± SEM).
