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Chemical structures of compounds 6 and 14, 20. The common substructure shared by the KLK5/KLK7 inhibitors is black. The substituents 2-methylthiophene (red), phenyl (blue) in 20 are replaced by benzyl (red), N-Cbz-l-proline (blue) moieties, respectively, in compounds 6 and 14. The green oxygen highlights the amide-to-ester substitution between 6 and 14.
