Table 4. Cellular Potency^a and Rat Pharmacokinetic Profile^b for Selected Piperidine-Ether Compounds.

compd	MK-5172	21	23	24	25	35	37
1b EC50, nM	1.5	0.25	0.21	0.53	0.73	0.48	0.62
3a EC50, nM	13.0	3.1	7.8	5.2	13.5	1.06	0.26
rat AUC, μM·h	0.7	2.7	0.01	2.3	2.8	0.01	1.2

^aCell-based replicon assays conducted in presence of 10% fetal-bovine serum (FBS); EC₅₀ determination was conducted using a TaqMan-based assay.

^b5 mg/kg, po, methyl cellulose (PEG400 for MK5172).