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. 2013 Aug 2;5(3):249–254. doi: 10.1021/ml400217r

Scheme 1. Synthetic Route.

Scheme 1

Reagents: (a) 4-chloro-6-methoxy-2-phenylpyrimidine, KOtBu, DMSO, 64 °C (87%); (b) 2,4,6-trivinylcycloboroxane pyridine complex, Pd(OAc)2, [(tBu)3PH]BF4, K2CO3, DME, H2O, microwave irradiation at 100 °C for 15 min (82%).