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| A156T |
D168V |
R155K |
||||
|---|---|---|---|---|---|---|
| compd | Ki ± SD (nM) | Va | Ki ± SD (nM) | Va | Ki ± SD (nM) | Va |
| 13 | 110 | 1.6 | 180 | 1.3 | 580 | 1.8 |
| 18L | 53 | 1.9 | 110 | 1.9 | 210 | 1.6 |
Vitality values (V) were calculated using the equation V = [Ki × (kcat/Km)]variant/[Ki × (kcat/Km)]wild-type.12
