Table 3. SAR of R3 Group.
| IC50 (μM) |
|||||
|---|---|---|---|---|---|
| compd | R3 | Plm I | Plm II | Plm IV | CatD |
| 3 | N(Pr)2 | 0.30 | 0.070 | 0.024 | 0.042 |
| 13 | NHPr | 0.75 | 0.50 | 0.038 | 0.11 |
| 14 | N(CH2)4 | 1.6 | 0.50 | 0.11 | 0.038 |
| 15 | NH2 | 7.6 | 4.4 | 0.17 | 0.50 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.