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. 2011 Oct 30;4(2):55–59. doi: 10.14802/jmd.11011

Figure 1.

Figure 1

Key discoveries regarding miRNA-based pathogenesis in PD. A: miR-133b suppresses the translation of Pitx3, and Pitx3 activates the transcription of miR-133b, providing negative reciprocal interaction. Pitx3 regulates dopaminergic cell differentiation. B: The 3′ UTR of SNCA, the α-synuclein gene, contains three putative loci predicted by TargetScan program (miR-7, miR-153, and miR-223 binding sites). C: Mutant LRRK2 reduces Let-7 and miR-184, which increases the E2F1 and DP1 transcription complex and induces abortive cell divisions and cell death of dopaminergic neurons. LRRK2: leucine-rich repeat kinase 2, mRNA: messenger RNAs, miR: microRNA. SNCA: synuclein alpha gene. UTR: untran-slated region.