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| cytochrome
P450 inhibition |
||||||
|---|---|---|---|---|---|---|
| coincubation (IC50, μM) |
preincubation
(IC50, μM) |
|||||
| compound | 3A4 | 2D6 | 2C9 | 3A4 | 2D6 | 2C9 |
| 13 | 4.9 | >30 | >30 | 0.3 | >30 | >30 |
| 9 | 2.1 | >30 | >30 | <0.3 | >30 | >30 |
| 11a | >30 | >30 | >30 | 7.5 | >30 | >30 |
| 12 | 13.3 | >30 | >30 | 0.9 | >30 | >30 |
