Figure 2.

Inhibition of PfCRT^CQR-mediated CQ transport by the resistance-reversers PZ, CP, PQ, VP, and by analogues of CP. (A) [³H]CQ uptake into oocytes expressing PfCRT^CQR (red bars) or PfCRT^CQS (blue bars) in the presence of 100 μM PQ, CP, PZ, or VP. (B) [³H]CQ uptake into oocytes expressing PfCRT^CQR (red bars) or PfCRT^CQS (blue bars) in the presence of CP analogues (100 μM). The level of inhibition by CP is shown as a solid line with SEM (n = 5) represented by red dashed lines. (C) Effects of VP, CP, and the CP analogues 23a, 15c, 12a, and 17c on [³H]CQ accumulation by erythrocytes infected with C2^GCO3, C4^Dd2, or C6^7G8 parasites. [See Supporting Information for further details.]