Table 3. CYP and hERG Inhibition of Coumarin.

	CYP inhibition IC50 (μM)a
compd	2C9 (−/+)	3A4 (−/+)	hERG inhibitonb (%)
11a	29/96	13/5.6	ND
11d	>100/>100	>100/>100	ND
14	19/19	26/11	25
1	12/60	>100/>100	no inhibition

^aIC₅₀ (−) and IC₅₀ (+) values were determined after a 30 min preincubation without and with NADPH, respectively.

^bAt 10 μM.