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. 2013 Dec 10;5(2):143–148. doi: 10.1021/ml400397k

Figure 2.

Figure 2

Screening of daidzein analogs identifies several molecules that show enhanced osteogenesis of MSCs compared to daidzein. MSCs from (A) Donor 1, (B) Donor 2, and Donor 3 were induced to undergo osteogenic differentiation and simultaneously exposed to vehicle (DMSO), estrogen (10 nM), daidzein (1 μM), or daidzein analogs (1 μM) at every medium change. After 14 days in osteogenic differentiation media, bone differentiation potential was determined relative to vehicle-treated cells normalized to 1.0. *, P < 0.05; #, P < 0.01; **, P < 0.001.