Table 1. In Vitro Activity of the Analogues Inspired by BTZ043 against the H37Rv Strain of Mtb in 7H12 and GAS Media (MIC in μM)^a.

	R1	R2	MABA: 7H12 (μM)	MABA: GAS (μM)
8	CF3	NO2	6.99	10.2
9	NO2	NO2	1.53	2.05
10	CF3	Br	>10	nd
11	CF3	Ph	>64	17.4
12	CF3	pyridine-N-oxide	>64	>64
13	CF3	pyridine	>50	49.3
17	CF3	H	>50	17.9
18	CF3	NO2	23.0	18.4
19	NO2	NO2	47.9	22.6
23	CF3	NO2	>50	2.03
24	NO2	NO2	13.03	0.27
BTZ043			<0.02	<0.02

^aMABA, microplate alamar blue assay; GAS, glycerol-alanine-salts medium; 7H12, 7H9 medium plus casitone, palmitic acid, albumin, and catalase.