Table 2. SAR Analysis of Aryl Substituents.

cmpd	R1	R2	R3	Pf 3D7 IC50 (μM)	cLogP
10a	cHex	3-OMe	3-OMe	0.768	3.9
(±)-10b	cHex	4-OMe	H	0.533	4.1
(±)-10c	cHex	3-OMe	H	0.917	4.1
10d	cHex	4-OCF3	4-OCF3	2.20	7.1
10e	cHex	4-OEt	4-OEt	0.466	4.6
10f	cHex	4-Me	4-Me	1.26	5.3
10g	cHex	3-Me	3-Me	0.533	5.3
10h	cHex	4-Cl	4-Cl	1.07	5.5
10i	cHex	3-Cl	3-Cl	1.06	5.5
(±)-10j	cHex	3-Ph	4-OMe	1.49	5.7
(±)-10k	cHex	3-(3-pyr)	4-OMe	0.595	4.5
(±)-10l	cHex	3-(3-pyr)	3-OMe	0.787	4.5
(±)-10m	cHex	3-(3-pyr)	H	0.75	4.7
(±)-10n	cHex	3-(2-pyr)	4-OMe	1.81	4.9
(±)-10o	cHex	3-(4-pyr)	3-OMe	0.318	4.5
10p	cHex	3-(3-pyr)	3-(3-pyr)	0.725	5.1
(±)-10q	cHex	3-OPh	H	0.424	5.7
(±)-10r	cHex	3-OBn	H	0.641	5.8
(±)-11	Me	3-(3-pyr)	H	6.88	5.8