Table 3. Oral in Vivo Efficacy of Lead Compounds (P. chabaudi ASS-Infected Murine Four-Day Suppressive Test).

			plasma [cmpd]d (ng/mL)
cmpd	dose (mpk)b	%Inh of parasitemiac	1 h	6 h	24 h
CQ	4.5	99.99	nda	nd	nd
8p	100	89	2790	3393	575
9a	110	63	4140e	nd	29
9f	100	73	2517	2187	7
9g	100	41	10363	3027	123

^and = not determined.

^bFour hours after infection, compounds were dosed orally once daily for four days.

^cDetermined on Day 4 postinoculation.

^dCompound concentration in the plasma determined 1, 6, and 24 h post last dose on Day 3.

^eDetermined at 30 min post dose.