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. 2014 May 19;55(5):3150–3157. doi: 10.1167/iovs.14-13995

Figure 4.

Figure 4

Rod-mediated function deteriorated in 12-month-old VLC-PUFAs–deficient mice. (A) Representative ERG response to Log 2.0 cd.s/m2 from WT, Het, and KO mice. (B) The KO rod (a-wave) and bipolar (b-wave) responses to increasing light intensities had lower amplitudes compared to WT and Het mice. (C) Maximum rod response (Rmp3) from the KO (201.3 ± 11.21) mice was lower than the responses from the WT (259.5 ± 20.73) and Het (257.0 ± 19.58) mice. (D) Rod Rmp3 sensitivity was increased in Het (91.6 ± 12.61) mice, but was not different between the WT (44.2 ± 3.57) and KO (52.8 ± 4.8) mice. (E) Maximum bipolar response (Vmax) from the KO mice was lower than the responses from WT and Het mice. (F) The b-/a-wave ratio was lower in KO (1.92 ± 0.11) compared to WT (2.19 ± 0.06) and Het (2.45 ± 0.13) mice (n = 8 WT, 6 Het, and 6 KO). Data are represented as the mean ± SEM. ns, not significant.