Analysis of cones in Elovl4 WT and KO mice. (A) Responses to white light, medium wavelength green light, and short wavelength blue light were similar in age-matched WT and KO mice at 5 weeks and 12 months of age. (B) Cone response times were not different between age-matched WT and KO mice. (C) Cone flicker responses (b-wave) to indicated frequencies showed no differences between WT and KO mice at 12 months of age. (D) The PNA immunolabeling of cone outer segment sheaths and cone pedicles indicated similar cone distribution between 12-month-old WT and KO mice. Scale bars: 50 μm; 5-week (n = 10 WT, 5 Het, and 10 KO). 12-month (n = 8 WT, 7 Het, and 8 KO). The ERG response data are expressed as mean ± SEM.