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. 2014 Feb 21;44(5):1481–1489. doi: 10.3892/ijo.2014.2309

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Copyright © 2014, Spandidos Publications

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Figure 4. — A–C, IP regulates the expression of BMI-1, and CD133 proteins possibly via the cyclin D1 and Cdc2 pathways in CA9-22 cells. IP-induced CD44 was not affected by incubating cells with AVP (cyclin D1 inhibitor) and catharidic acid (Cdc2 inhibitor) in CA9-22 cell cultures. While the expression of CD133, Bmi-1, Cdc2 and CD1 proteins were fully blocked by the addition of AVP, catharidic acid and cycloheximide (CH). This suggests that IP regulates the expression of Bmi-1, CD133 and CD44 via the cyclin D1 and Cdc2 signaling pathways. ^*p<0.05.