Table 3.
Genotypic effect of the chromosome 4 QTL contributing to variations in metabolic syndrome-related phenotypes and atherosclerotic lesion area in [(PERAxB6-Ldlr−/−)F1 × B6-Ldlr−/−]N2 mice grouped by genotype at the peak linked marker, D4Mit143. Data are expressed as mean ± SD.
| Genotype | Lesion area (μm2/section) | TG (mg/dl) | BWTch(g) | BWTWTD(g) | Insulin (ng/ml) | Leptin (ng/ml) | Non HDL-C (mg/dl) | HDL-C (mg/dl) |
|---|---|---|---|---|---|---|---|---|
| Males | ||||||||
| BB (n=45) | (21.7±10)×104 | 408±141 | 25.4±4 | 29.9±5 | 3.18±2 | 11.8±11 | 356±96 | 69±18 |
| BP (n=30) | (28.3±9)×104* | 639±317† | 28.0±4* | 33.3±5* | 4.86±3‡ | 19.3±18§ | 381±111 | 67±20 |
| Females | ||||||||
| BB (n=41) | (32.7±11)×104 | 242±112 | 19.0±2 | 21.4±3 | 1.17±0.8 | 18.3±12 | 286±72 | 57±17 |
| BP (n=51) | (31.6±12)×104 | 348±266§ | 20.5±2.8* | 23.6±3.9* | 1.03±0.9 | 26.1±15§ | 351±128‡ | 53±17 |
BWTch, body weight after feeding a chow diet; BWTWTD, body weight after feeding a Western-type diet. All other traits were measured from mice fed a high fat Western-type diet. BB, homozygous for B6 alleles; BP, heterozygous for B6 and PERA/Ei alleles.
*
p ≤ 0.005 vs. BB
†
p <0.0001 vs. BB
‡
p <0.009 vs. BB
§
p ≤ 0.03 vs. BB