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Representative chromatograms of plasma samples from rats subcutaneously dosed by 1 mg/kg COT: (A) chromatograms of COT and IS in samples that were diluted 15 folds with blank plasma, with the original COT concentration of ng/mL; (B) chromatograms of NCOT and IS, with NCOT concentration below LLOQ; (C) chromatograms of OHCOT and IS, with OHCOT concentration of ng/mL; (D) chromatograms of COTNO and IS, with COTNO concentration of ng/mL.
