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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Dev Dyn. 2013 Jun 3;242(7):817–831. doi: 10.1002/dvdy.23969

Figure 3.

Figure 3

Defects in cranial development in Class I meis morphants. A, lateral view of a 5dpf larva injected with 5ng meis1 ATG Morpholino. B, ventral view of the craniofacial skeleton of an uninjected larva at 5dpf. C, ventral view of a meis1 ATG morphant showing a fusion between the Meckel’s and palatoquadrate cartilages and the ceratohyal and first ceratobranchial (asterisk). Ectopic cartilage is indicated by an arrowhead. D, lateral view of a flat mount showing a fused Meckel’s and palatoquadrate cartilage and the hyosymplectic. E, ventral view of flat mount showing ectopic cartilage (arrowhead) and fused ceratobranchials (asterisk). F, ventral view of a larval skeleton 5 days after injection with 20ng meis1 SPL Morpholino. G, ventral view of a larval skeleton after co-injection with 20ng meis1 SPL Morpholino and 2ng meis1 ATG Morpholino. Ectopic cartilage is indicated by an arrowhead and the fusion between Meckel’s and the palatoquadrate is indicated by the asterisk. H, lateral view of a 5dpf larva injected with 10ng meis2a Morpholino. I, ventral view of the skeleton of a meis2a ATG morphant. J, flat mount of a meis2a morphant (5ng ATG MO) indicating a fusion between Meckel’s and palatoquadrate (asterisk) and ectopic cartilage (arrowhead). Abbreviations as in Figure 1.