Figure 1.

A workflow of DNA microarray-based approach for screening candidate genes for type 2 diabetes. Scheme showing the steps involved in candidate gene enrichment. First, differentially expressed genes (DEGs) between pre- and postdiabetic mice are extracted. Diabetes-dependent genes are then extracted by excluding age-dependent DEGs in diabetic mice. DEGs in response to aging in normal mice are defined as age-dependent genes. Venn diagram showing overlaps in upregulated entities between diabetic and normal mice. Of the 526 entities, which were upregulated in the postdiabetic stage, 413 and 113 were determined to be diabetes-dependent and age-dependent entities, respectively.