Table 3.
Florbenazine SUVR by Clinical Diagnosis for each striatal region
| HC | PD | AD | DLB | P value | Pair-wise comparison | |
|---|---|---|---|---|---|---|
| Whole striatum* |
2.84 (0.552) |
1.72 (0.172) |
3.04 (0.579) |
1.87 (0.372) |
0.0001 |
a, c, d, f |
| Caudate |
2.60(0.529) |
1.77 (0.415) |
2.21 (0.458) |
1.79 (0.418) |
0.0303 |
c, f |
| Anterior putamen |
2.98 (0.601) |
1.86 (0.084) |
3.39 (0.744) |
2.05 (0.519) |
0.0003 |
a, c, d, f |
| Posterior putamen |
2.93 (0.529) |
1.53 (0.104) |
3.52 (0.758) |
1.78 (0.400) |
<0.0001 |
a, c, d, f |
| Lower posterior putamen** |
2.82 (0.474) |
1.46 (0.120) |
3.41 (0.753) |
1.67 (0.427) |
<0.0001 |
a, c, d, f |
| Laterality index*** |
0.94 (0.029) |
0.91 (0.043) |
0.94 (0.032) |
0.88 (0.105) |
0.5582 |
|
| Caudate/putamen ratio**** | 0.88 (0.035) | 1.15 (0.240) | 0.64 (0.151) | 1.03 (0.240) | 0.0011 | b, d, f |
*Average of left and right caudate, anterior putamen and posterior putamen.
**Posterior putamen with lower SUVr for each subject.
***Ratio of lower to higher posterior putamen for each subject. A higher value indicates greater asymmetry.
****Ratio of average caudate (left and right) to average posterior putamen (left and right). A higher value indicates greater difference between the caudate and posterior putamen.
Mean SUVr values (and SD) are given for each group. P-values are for the overall group comparison from Kruskal-Wallis test. Subsequent pair-wise comparisons are noted by the letters in the last column if the overall comparison was significant (p value < 0.05; a = HC vs. PD; b = HC vs. AD; c = HC vs. DLB; d = PD vs. AD; e = PD vs. DLB; f = AD vs. DLB).