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. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Arch Environ Contam Toxicol. 2013 Dec 25;66(2):248–258. doi: 10.1007/s00244-013-9981-6

Table 3. Independence metrics for the toxicity of ethyl α-halogenated acetate:α-halogenated acetonitrile mixtures.

		15-min			30-min			45-min

Agent A^a	Agent B^b	EC₅₀-IQ^c	mIQ^d	DV-I^e	EC₅₀-IQ	mIQ	DV-I	EC₅₀-IQ	mIQ	DV-I
EIAC	IAN	*0.94*^f	*0.97*	*0.07*	*0.98*	*1.01*	*0.02*	*1.02*	*1.04*	*1.04*
EIAC	BRAN	*0.98*	*0.99*	*0.06*	*1.01*	*1.03*	*0.03*	*0.98*	*0.99*	*0.03*
EIAC	CLAN	*0.93*	*0.93*	*0.07*	*0.97*	*0.98*	*0.03*	*0.99*	*0.99*	*0.04*
EBAC	IAN	*0.96*	*0.99*	*0.05*	*0.97*	*1.00*	*0.02*	*0.98*	*1.01*	*0.04*
EBAC	BRAN	*1.00*	*1.01*	*0.07*	*1.07*	*1.10*	*0.10*	*1.08*	1.11	0.11
EBAC	CLAN	*0.99*	*1.01*	*0.02*	*1.02*	*1.07*	*0.07*	*1.07*	1.13	0.13
ECAC	IAN	1.18	1.30	0.30	*1.10*	1.16	0.18	*1.04*	1.11	0.11
ECAC	BRAN	1.20	1.30	0.31	1.20	1.27	0.28	1.17	1.23	0.23
ECAC	CLAN	1.20	1.30	0.30	1.13	1.17	0.21	1.14	1.20	0.20
EFAC	IAN	*0.93*	*1.03*	0.19	*1.10*	1.20	0.20	1.15	1.21	0.21
EFAC	BRAN	1.15	1.21	0.21	*1.08*	1.12	0.13	1.17	1.20	0.20
EFAC	CLAN	*1.06*	1.13	0.13	*1.10*	1.15	0.15	1.15	1.19	0.19

^a

EIAC – ethyl iodoacetate, EBAC – ethyl bromoacetate, ECAC – ethyl chloroacetate, EFAC – ethyl fluoroacetate

^b

IAN – iodoacetonitrile, BRAN – bromoacetonitrile, CLAN – chloroacetonitrile

^c

EC₅₀-IQ – EC₅₀-independence quotient = experimental EC₅₀ / predicted independence EC₅₀

^d

mIQ – mean independence quotient = EC₂₅-IQ + EC₅₀-IQ + EC₇₅-IQ / 3

^e

DV-I – independence quotient deviation value (see text for calculation details)

^f

values in bolded, italicized typeface are consistent with independence