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. 2013 Sep 10;2(9):e121. doi: 10.1038/mtna.2013.45

Figure 2.

Figure 2

Time- and dose-dependent kinetics of Bcl-2 inhibition by systemically administered nanoliposomal (NL)-Bcl-2-siRNA in MDA-MB-231 orthotopic xenograft model. (a) Mice-bearing MDA-MB-231 tumors were injected with a single i.v. dose of NL-Control-siRNA or NL-Bcl-2-siRNA (0.075 or 0.15 mg siRNA/kg from tail vein) and tumors were removed on days 2, 4 and 6. Inhibition of Bcl-2 protein expression was detected by western blot analysis of tumor lysates. (b) Inhibition of Bcl-2 protein expression by densitometric analysis of bands shown in 1A tumors.