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. Author manuscript; available in PMC: 2014 May 20.
Published in final edited form as: Neurosurgery. 2011 Sep;69(3):706–712. doi: 10.1227/NEU.0b013e3182181b67

Fig. 6.

Fig. 6

Drug Concentration parameters: The peak concentration (μg/g, A) and peak duration (seconds, B) was comparable between the Cerebral Hypoperfusion (CHP, n=8) and the normal perfusion (NP, n=5) groups but the area under the concentration time curve (μg/g*min) was showed a trend towards an increase with CHP (C). The final concentrations (μg/g, D) at the end of twenty minutes were similar in the NP and CHP groups. In animals with breeched BBB, there seems to be no sustained benefit of injecting mitoxantrone during CHP.