Table 1.
Changes in physiological parameters during transient cerebral hypoperfusion
| Base | IC-Mannitol | CHP | CHP+ IC-MTO | 5 min Post MTO | 20 min post MTO | ||
|---|---|---|---|---|---|---|---|
| Temperature (°C) | CHP | 36.1±1.1 | 36.2 ±1.1 | 36.1±1.1 | 36.1±1.1 | 36.1±1.1 | 36.1±1.1 |
| NP | 36.1±1.0 | 35.1 ± 1.3 | 36.2±0.8 | 36.2±0.8 | 36.2±0.8 | 36.3±1.1 | |
| Resp. rate (Breaths/min) | CHP | 62±15 | 62±15 | 62±15 | 62±15 | 62±15 | 62±15 |
| NP | 64±6 | 64±6 | 64±6 | 64±6 | 64±6 | 64±6 | |
| Heart rate (beats/min) | CHP | 235±24 | 226±23 | 120±71@* | 160±75** | 212±28 | 231±20 |
| NP | 246±17 | 226±27 | 215±32 | 212±28 | 234±22 | 242±26 | |
| Mean arterial pressure (mm Hg) | CHP | 95±6 | 100±12 | 32±21@* | 27±14@** | 98±17 | 88±16 |
| NP | 99±10 | 107±16 | 89±26 | 86±26 | 97±4 | 95±5 | |
| End-tidal CO2 (mm Hg) | CHP | 40±7 | 38±10 | 26±11@* | 25±11@** | 40±7 | 40±7 |
| NP | 40±6 | 39±5 | 38±5 | 38±5 | 40±8 | 42±13 | |
| %Δ cerebral blood flow from baseline | CHP | 100±0 | 134±85 | 13±8@* | 44±46@** | 136±74 | 101±74 |
| NP | 100±0 | 138±110 | 104±23 | 96±19 | 110±16 | 84±20 |
Table legend: Abbreviations: CHP: transient cerebral hypoperfusion (n=8); NP: normal perfusion (n=5); IC: intracarotid; MTO: mitoxantrone; IC: intracarotid.
Symbols:
@
significant difference between CHP and NP (P<0.05);
*
Significant difference between CHP and other stages of the experiment (P<0.0033);
**
significant differences between MTO and other stages of the experiment.