Proposed scheme for risk stratification for the end point of ACA or SCD in LQT2 patients by gender, mutation location, QTc, and a history of prior syncope.
*Hazard ratios and score estimates were obtained from a multivariate Cox model that included interactions among the identified risk factors (categorized by QTc duration, time-dependent syncope, gender and mutation-location) ; decimals points in HRs are rounded to the nearest whole number.; event rates per 100 person-years were calculated by dividing the number of life-threatening cardiac events (comprising ACA or SCD) in each risk category by the total follow-up time in the category (with follow-up censored after the occurrence of a ACA) and multiplying the result by 100.
ACA = aborted cardiac arrest; SCD = sudden cardiac death.