Table 1.
Baseline and follow-up characteristics of the study population by gender
| Characteristics | Male | Female | P-value |
|---|---|---|---|
|
| |||
| N=490 | N=676 | ||
|
| |||
| QTc (msec) | |||
| Continuous | 478 ± 57 | 484 ± 52 | 0.02 |
| ≥500, % | 32 | 34 | 0.44 |
|
| |||
| RR (sec) | 860 ± 250 | 856 ±216 | 0.91 |
|
| |||
| Location of mutation | |||
| Pore-loop, % | 28 | 28 | 0.93 |
| Nonpore-loop: | |||
| TM, % | 4 | 4 | 0.98 |
| N-term/C-term, % | 35 | 34 | 0.98 |
|
| |||
| Type of mutation | |||
| Missense, % | 65 | 68 | 0.33 |
| Non-missense, % | 35 | 32 | |
|
| |||
| LQTS-Therapies | |||
| β-blockers, % | 52 | 55 | 0.22 |
| Pacemaker, % | 3 | 6 | 0.02 |
| LSCD, % | 0.6 | 2 | 0.12 |
| ICD, % | 8 | 16 | <0.001 |
|
| |||
| Cardiac events during follow-up | |||
| Syncope, % | 24 | 46 | <0.001 |
| ACA, % | 3 | 9 | <0.001 |
| SCD, % | 8 | 12 | 0.02 |
| Appropriate ICD shocks, % | 1.5 | 1.9 | 0.58 |
|
| |||
| First SCD or ACA, %* | 10 | 19 | <0.001 |
Plus – minus values are means ± SD.
ACA = aborted cardiac arrest; ICD = implantable cardioverter defibrillator; LCSD = left cervical sympathetic denervation; SCD = sudden cardiac death; TM = transmembrane
*
Only the first event for each patient was considered.