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THP-1 cells were pre-treated with Cytochalasin D for 4 hrs and challenged with 6 µM round (A) or irregular (B) particles . THP-1 cell secretion of IL-1β was analyzed 24 hrs after culture. (C) THP-1 phagocytosis inhibition was confirmed by confocal microscopy 24 hrs after culture. * denotes significance at p < 0.05.
