Table 3.
Fluid assay results
| Biomarker
|
Acute ACL patients’ serum (n = 4)
|
Normal subjects’ serum
|
ACL patients’ synovial fluid (n= 4)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Marker | Units | Mean | SD | Mean | SD | n | Mean | SD |
| Trap5b | U/L | 0.229 | 0.067 | 3.17 | 0.73 | 28 | 3.98 | 2.21 |
| BSP | ng/mg | 84.1 | 31.0 | 32.3 | 21.9 | 28 | 73 | 31 |
| BAP | mg/mg | 0.095 | 0.021 | 0.072 | 0.031 | 10 | 0.009 | 0.006 |
| C2C | ng/mg | 705 | 99 | 759 | 156 | 15 | 802 | 416 |
| CS3B3 | ng/mg | 28.4 | 8.48 | 4.74 | 2.24 | 27 | 1.07 | 0.72 |
Notes: ACL serum change from normal: TRAP5b down (P = 0.001); BSP up (P < 0.001); BAP up (P = 0.137); C2C down (P = 0.520); CS3B3 up (P < 0.001).
Abbreviations: ACL, anterior cruciate ligament; BAP, bone alkaline phosphatase; BSP, bone sialoprotein; C2C, collagen 2 cleavage neoepitope; CS3B3, chondroitin sulfate epitope; SD, standard deviation; Trap5b, tartrate-resistant alkaline phosphatase.