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The menin-PRMT5 complex inhibits GLI1 transcriptional activity. (A) Relative luciferase activity in Men1-null MEFs expressing a luciferase reporter under control of the Gli1-responsive promoter co-transfected with cDNA's for GLI1, Menin, PRMT5-WT and PRMT5 (R368A) mutant as indicated. Values obtained were normalized to renilla luciferase activity. (B) Inputs for cell lysates used in Fig. 4A. Error bars indicate ± s.d.
