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. 2014 Jan 31;25(5):461–474. doi: 10.1089/hum.2013.200

FIG. 5.

FIG. 5.

Treatment with AAV2/1-miRNA-Htt partially corrects the transcriptional dysregulation of DARPP-32 and D1 receptor in YAC128 mice. DARPP-32 and D1 receptor mRNA levels in the striatum of YAC128 and wild-type (WT) mice were assessed by qPCR 3 months after the injection of either AAV2/1-miRNA-Htt (YAC, n=8; WT, n=8) or AAV2/1-Null control (YAC, n=8; WT, n=8). (A) Striatal DARPP-32 mRNA levels in YAC128 and FVB wild-type littermate mice after AAV2/1-Null or AAV2/1-miRNA-Htt treatment. (B) Striatal D1 receptor mRNA levels in YAC128 and FVB wild-type littermate mice after AAV2/1-Null or AAV2/1-miRNA-Htt treatment. Values are given as means±SEM. *Significant difference, p<0.05; ANOVA followed by Tukey post-hoc test.