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. Author manuscript; available in PMC: 2014 May 20.
Published in final edited form as: Arthritis Rheum. 2011 Aug;63(8):2407–2415. doi: 10.1002/art.30399

Table 2.

Serologic and clinical profiles of patients with SLE in the IFNhigh, IFNlow/AIAA-positive, and IFNlow/AIAA-negative subgroups*

IFNlow
IFNhigh vs. IFNlow/AIAA positive
IFNhigh vs. IFNlow/AIAA negative
Parameter IFNhigh AIAA positive AIAA negative P† Adjusted P‡ P† Adjusted P‡
BAFF, pg/ml 6,107 (2,291–22,170) 2,447 (1,974–3,872) 2,338 (1,043–7,892) <0.0001 <0.0014 <0.0001 <0.0014
IFN signature metric   5.74 (2.3–14.9)   2.83 (0.6–5.8)     1.5 (0.6–3.9)   0.0006   0.0031 <0.0001 <0.0014
Serum type I IFN bioactivity§ 8,839 (1,895–40,144) 2,704 (2,291–4,785) 2,620 (1,491–3,709)   0.002   0.0072 <0.0001 <0.0014
Autoantibody profile, LU
 Anti-histone        4 (1–10)        1 (0–7)        1 (0–8)   0.0236   0.042   0.001   0.0045
 Anti-chromatin    106 (10–585)      15 (8–101)      13 (8–146)   0.0027   0.0088   0.0002   0.0014
 Anti-ribosomal P      12 (7–233)        8 (6–13)        8 (6–18)   0.0049   0.0147   0.0086   0.022
 Anti-dsDNA    395 (40–826)    125 (19–577)      82 (20–698)   0.0543   0.075   0.0014   0.0056
 Anti-SSB        5 (4–195)        5 (4–16)        5 (4–13)   0.1187   0.153   0.504   0.550
 Anti-SSA      33 (6–310)        9 (5–306)        7 (6–328)   0.461   0.519   0.813   0.813
 Anti-Sm      10 (4–159)        5 (4–181)        5 (4–22)   0.510   0.540   0.02   0.040
 Anti-RNP      31 (4–200)        6 (3–244)        6 (3–280)   0.330   0.383   0.020   0.040
C4, mg/dl        8 (3–24)      19 (8–138)   23.5 (4–49)   0.0177   0.040   0.011   0.026
C3, mg/dl      74 (39–141)    107 (35–133)    104 (49–157)   0.0275   0.045   0.022   0.042
SLEDAI        8 (0–12)        4 (2–6)        4 (0–12)   0.0297   0.047   0.07   0.093
BLC, pg/ml 1,281 (549–6,208)    812 (373–3,127)    686 (346–2,242)   0.0391   0.059   0.026   0.044
IP-10, pg/ml    258 (96–5,207)    149 (41–1,317)    148 (66–747)   0.052   0.075   0.0005   0.003
MCP-1, pg/ml    455 (93–2,689)    374 (203–742)    294 (68–702)   0.2581   0.310   0.007   0.019
I-TAC, pg/ml    106 (31–930)    101 (28–875)      86 (20–542)   0.579   0.595   0.168   0.209
*

Values are the median (range). All data are from 49 female patients with systemic lupus erythematosus (SLE), with the exception of the SLE Disease Activity Index (SLEDAI; n = 46) and C3 and C4 (n = 45). All statistical analyses were based on available data. IFN = interferon; AIAA = anti-IFNα autoantibody; LU = luminex units; anti-dsDNA = anti-double-stranded DNA; BLC = B lymphocyte chemokine; IP-10 = IFN7-inducible 10-kd protein; MCP-1 = monocyte chemoattractant protein 1; I-TAC = IFN-inducible T cell a chemoattractant.

†

By Wilcoxon’s test.

‡

After Benjamini and Hochberg correction for multiple testing.

§

Luciferase units.