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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Osteoarthritis Cartilage. 2014 Jan 11;22(3):499–508. doi: 10.1016/j.joca.2013.12.019

Table I.

Histology score and microCT parameters and for medial and lateral femora or tibiae from knees of wild type and integrin α1-null mice (a), and anterior or posterior regions of medial and lateral calcified menisci (b). Analysed regions of trabecular bone (red shading), subchondral bone (blue shading) and calcified menisci (green shading) are illustrated in [Fig. 1(E, F)].

(a) Femur
Tibia
Medial Lateral Medial Lateral


Histology wild type α1-null wild type α1-null wild type α1-null wild type α1-null
Histology Score (/30) 6.11 ± 0.51 4.11 ± 1.02 6.00 ± 2.31 6.22 ± 2.22 6.22 ± 0.77 4.67 ± 0.88 6.00 ± 0.00 7.44 ± 1.68
Trabecular Bone
BV (mm3 ×10−1) 2.66 ± 0.15 2.77 ± 0.20 1.70 ± 0.13 1.75 ± 0.16 1.03 ± 0.39 1.03 ± 0.12 1.61 ± 0.22 1.38 ± 0.27
TV (mm3 ×10−1) 4.97 ± 0.59 5.08 ± 0.55 4.16 ± 0.61 4.09 ± 0.66 2.32 ± 0.86 2.44 ± 0.40 5.26 ± 0.49 4.14 ± 0.63
BV/TV ×10−2 54.1 ± 8.1 54.7 ± 3.0 41.0 ± 2.7 43.2 ± 4.2 44.6 ± 3.9 42.3 ± 2.5 30.8 ± 5.1 33.2 ± 3.5
Conn. Density 234.4 ± 45.5 229.8 ± 20.6 181.8 ± 37.7 178.1 ± 27.4 196.3 ± 11.0 244.3 ± 42.0 188.9 ± 48.2 228.2 ± 81.8
Tb. Thickness (mm ×10−2) 8.26 ± 1.58 7.81 ± 0.51 6.88 ± 0.31 7.04 ± 0.49 7.28 ± 0.30 6.57 ± 0.33 6.16 ± 0.55 6.07 ± 0.47
Tb. Space (mm ×10−1) 1.06 ± 0.08 1.01 ± 0.05 1.25 ± 0.04 1.19 ± 0.09 1.28 ± 0.19 1.24 ± 0.14 1.43 ± 0.23 1.29 ± 0.17
Tb. Number 7.29 ± 0.04 7.98 ± 0.20 6.94 ± 0.07 7.19 ± 0.21 8.09 ± 1.30 8.11 ± 0.92 7.07 ± 0.91 8.07 ± 0.84
Bone Den. (mg Ha/ccm) 925.3 ± 46.9 905.7 ± 15.7 906.8 ± 19.0 911.3 ± 20.4 943.3 ± 20.1 900.1 ± 13.6 889.0 ± 23.5 886.4 ± 14.6
App. Den. (mg Ha/ccm) 551.8 ± 71.9 544.4 ± 28.3 453.8 ± 22.5 471.3 ± 37.3 495.3 ± 34.0 467.7 ± 23.8 375.1 ± 43.5 396.2 ± 25.3
Subchondral Bone
Thickness (mm ×10−1) 1.25 ± 0.08 1.39 ± 0.08 1.65 ± 0.45 1.45 ± 0.19 0.82 ± 0.08 1.00 ± 0.07 1.24 ± 0.23 1.04 ± 0.07
TV (mm3 ×10−2) 9.68 ± 0.53 9.68 ± 0.59 4.94 ± 0.68 5.87 ± 0.49 8.02 ± 1.83 6.78 ± 2.08 4.53 ± 1.20 6.91 ± 0.79
App. Den. (mg Ha/ccm) 814.9 ± 25.7 798.4 ± 2.9 861.2 ± 20.5 875.9 ± 32.2 791.7 ± 26.2 809.6 ± 10.2 799.3 ± 23.2 768.9 ± 23.1
(b) Anterior Meniscus
Posterior Meniscus
Medial Lateral Medial Lateral
Calcified Menisci wild type α1-null wild type α1-null wild type α1-null wild type α1-null
TV (mm3 ×10−2) Δ 8.86 ± 3.41 7.13 ± 0.17 8.75 ± 0.70 9.27 ± 0.83 1.08 ± 0.64 1.61 ± 0.41 1.61 ± 0.32 2.19 ± 0.10
App. Den. (mg Ha/ccm) Δ 713.8 ± 14.4 671.6 ± 22.3 795.2 ± 6.0 820.0 ± 33.0 691.0 ± 25.4 668.1 ± 18.3 648.9 ± 30.5 683.1 ± 9.1

TV = Total Volume, BV = Bone Volume, BV/TV = Bone Volume/Total Volume, Conn. Density = Connectivity Density, Tb. = Trabecular, App. = Apparent, Den. = Density. Histology Score uses modified Mankin scheme1. N=3 independent measurements for each mean, ± 95% confidence interval. N=3 wildtype mice (age 184 days); N=3 integrin α1-null mice (age 182 days)

indicates femoral values significantly different from tibial values,

indicates medial values significantly different from lateral values,

Δ

indicates anterior values significantly different than posterior values.

P<0.05; specific P values in results section.