Table I.
(a) | Femur
|
Tibia
|
||||||
---|---|---|---|---|---|---|---|---|
Medial | Lateral | Medial | Lateral | |||||
|
|
|||||||
Histology | wild type | α1-null | wild type | α1-null | wild type | α1-null | wild type | α1-null |
Histology Score (/30) | 6.11 ± 0.51 | 4.11 ± 1.02 | 6.00 ± 2.31 | 6.22 ± 2.22 | 6.22 ± 0.77 | 4.67 ± 0.88 | 6.00 ± 0.00 | 7.44 ± 1.68 |
Trabecular Bone | ||||||||
BV (mm3 ×10−1) †‡ | 2.66 ± 0.15 | 2.77 ± 0.20 | 1.70 ± 0.13 | 1.75 ± 0.16 | 1.03 ± 0.39 | 1.03 ± 0.12 | 1.61 ± 0.22 | 1.38 ± 0.27 |
TV (mm3 ×10−1) †‡ | 4.97 ± 0.59 | 5.08 ± 0.55 | 4.16 ± 0.61 | 4.09 ± 0.66 | 2.32 ± 0.86 | 2.44 ± 0.40 | 5.26 ± 0.49 | 4.14 ± 0.63 |
BV/TV ×10−2 †‡ | 54.1 ± 8.1 | 54.7 ± 3.0 | 41.0 ± 2.7 | 43.2 ± 4.2 | 44.6 ± 3.9 | 42.3 ± 2.5 | 30.8 ± 5.1 | 33.2 ± 3.5 |
Conn. Density | 234.4 ± 45.5 | 229.8 ± 20.6 | 181.8 ± 37.7 | 178.1 ± 27.4 | 196.3 ± 11.0 | 244.3 ± 42.0 | 188.9 ± 48.2 | 228.2 ± 81.8 |
Tb. Thickness (mm ×10−2) †‡ | 8.26 ± 1.58 | 7.81 ± 0.51 | 6.88 ± 0.31 | 7.04 ± 0.49 | 7.28 ± 0.30 | 6.57 ± 0.33 | 6.16 ± 0.55 | 6.07 ± 0.47 |
Tb. Space (mm ×10−1) †‡ | 1.06 ± 0.08 | 1.01 ± 0.05 | 1.25 ± 0.04 | 1.19 ± 0.09 | 1.28 ± 0.19 | 1.24 ± 0.14 | 1.43 ± 0.23 | 1.29 ± 0.17 |
Tb. Number | 7.29 ± 0.04 | 7.98 ± 0.20 | 6.94 ± 0.07 | 7.19 ± 0.21 | 8.09 ± 1.30 | 8.11 ± 0.92 | 7.07 ± 0.91 | 8.07 ± 0.84 |
Bone Den. (mg Ha/ccm) | 925.3 ± 46.9 | 905.7 ± 15.7 | 906.8 ± 19.0 | 911.3 ± 20.4 | 943.3 ± 20.1 | 900.1 ± 13.6 | 889.0 ± 23.5 | 886.4 ± 14.6 |
App. Den. (mg Ha/ccm) | 551.8 ± 71.9 | 544.4 ± 28.3 | 453.8 ± 22.5 | 471.3 ± 37.3 | 495.3 ± 34.0 | 467.7 ± 23.8 | 375.1 ± 43.5 | 396.2 ± 25.3 |
Subchondral Bone | ||||||||
Thickness (mm ×10−1) †‡ | 1.25 ± 0.08 | 1.39 ± 0.08 | 1.65 ± 0.45 | 1.45 ± 0.19 | 0.82 ± 0.08 | 1.00 ± 0.07 | 1.24 ± 0.23 | 1.04 ± 0.07 |
TV (mm3 ×10−2) | 9.68 ± 0.53 | 9.68 ± 0.59 | 4.94 ± 0.68 | 5.87 ± 0.49 | 8.02 ± 1.83 | 6.78 ± 2.08 | 4.53 ± 1.20 | 6.91 ± 0.79 |
App. Den. (mg Ha/ccm) † | 814.9 ± 25.7 | 798.4 ± 2.9 | 861.2 ± 20.5 | 875.9 ± 32.2 | 791.7 ± 26.2 | 809.6 ± 10.2 | 799.3 ± 23.2 | 768.9 ± 23.1 |
(b) | Anterior Meniscus
|
Posterior Meniscus
|
||||||
---|---|---|---|---|---|---|---|---|
Medial | Lateral | Medial | Lateral | |||||
Calcified Menisci | wild type | α1-null | wild type | α1-null | wild type | α1-null | wild type | α1-null |
TV (mm3 ×10−2) Δ | 8.86 ± 3.41 | 7.13 ± 0.17 | 8.75 ± 0.70 | 9.27 ± 0.83 | 1.08 ± 0.64 | 1.61 ± 0.41 | 1.61 ± 0.32 | 2.19 ± 0.10 |
App. Den. (mg Ha/ccm) Δ | 713.8 ± 14.4 | 671.6 ± 22.3 | 795.2 ± 6.0 | 820.0 ± 33.0 | 691.0 ± 25.4 | 668.1 ± 18.3 | 648.9 ± 30.5 | 683.1 ± 9.1 |
TV = Total Volume, BV = Bone Volume, BV/TV = Bone Volume/Total Volume, Conn. Density = Connectivity Density, Tb. = Trabecular, App. = Apparent, Den. = Density. Histology Score uses modified Mankin scheme1. N=3 independent measurements for each mean, ± 95% confidence interval. N=3 wildtype mice (age 184 days); N=3 integrin α1-null mice (age 182 days)
indicates femoral values significantly different from tibial values,
indicates medial values significantly different from lateral values,
indicates anterior values significantly different than posterior values.
P<0.05; specific P values in results section.