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. 2014 May 20;9(5):e98079. doi: 10.1371/journal.pone.0098079

Figure 6. Δ9-THC reduces METH-induced astrogliosis in the PFC.

Figure 6

A. Rats were treated as described in the legend of Figure 4. Pre- and Post-administration of Δ9-THC attenuated the astrogliosis induced by METH (Pre: −34% and −37%, Post: −47% and −29%, for 1 and 3 mg/kg, respectively) compared to control groups. **p<0.01 vs PRE METH-VEH and # p<0.05, and ### p<0.001 vs POST METH-VEH (Bonferroni's post-hoc test). Horizontal dot lines represent the values of percentage of GFAP-IR density (1.31±0.10) in SAL-VEH group. B. Representative images of GFAP immunostaining in the PFC 72 h after the last METH or SAL administration in SAL-VEH, METH-VEH, METH- Δ9-THC 1 and 3 mg. Scale bar  =  100 µm.