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. 2014 May 20;9(5):e98079. doi: 10.1371/journal.pone.0098079

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© 2014 Castelli et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Rats received injections of 1/kg Δ9-THC or VEH at 0.5, 12, 24, 36 and 48 h after the last METH administration (Post-treatment, POST) and were sacrificed 3 days after the last METH injection. SR (1 mg/kg, i.p.) or VEH were administered 15 min before each Δ9-THC or VEH injection. Two-way ANOVA in the CPu (A) showed a significant Δ9-THC x SR interaction (F_(1,40) = 32.45, p<0.0001); the administration of SR blunted the effect of Δ9-THC on METH-induced nNOS over-expression. SR alone decreased nNOS labeled neurons compared to that of control. ***p<0.001 vs METH-VEH (VEH pretreated) and ^##p<0.01 vs METH-VEH-Δ9-THC (VEH pretreated). B. Two-way ANOVA for GFAP-IR revealed a significant interaction between Δ9-THC and SR in the CPu (F_(1,35) = 19.86, p<0001). Δ9-THC and SR, alone or in combination, attenuated the METH-induced increase of GFAP-IR in the CPu. ***p<0.001 vs METH-VEH (VEH pretreated).