Figure 2. Structural analysis of lungs from Ulk1/2 DKO and Atg5 KO mice. Lungs from Ulk1/2 Ctrl; Ulk1/2 DKO; Atg5 Ctrl and Atg5 KO embryos at ED18.5 were prepared for transmission electron microscopy as described in Materials and Methods. (A) Ulk1/2 DKO and Atg5 KO mice display glycogen-filled alveolar type II cells, indicated by arrowheads. Alveolar type I and II cells are indicated by arrows in upper left and right panel (Ulk1/2 and Atg5 Ctrl). Scale bar: 2 μm. (B) The alveolar type II cells of Ulk1/2 DKO and Atg5 KO mice contain lamellar bodies (see arrows) that are similar in number and structure to those found in alveolar type II cells of littermate controls. Scale bar: 500 nm.